Monday, May 3, 2010

Who Makes Driglo Nappies

resistance to botulinum toxin Botox Injection

4 days after my second botox injection, I'm back at the optometrist this morning, to the same conclusion as last time: nothing happens. Or almost.
Yet he "put the dose (more than 10 IU), yet it I have not passed in the late morning, and yet her other patients have reacted well, some very next day. So we can not accuse a technical problem.

So according to the ophthalmologist, the hypothesis of immunological resistance is very unlikely for several reasons:
- the existence of resistance due to antibodies neutralizing botulinum toxin has not been proven,
- the doses used in ophthalmology are far too small to trigger such a reaction,
- the appearance of antibodies can be done only after several repeated injections, and certainly not soon the first time
- I asked if it was possible that one day I have eaten food contaminated with botulinum toxin and this has triggered an immune response, response: "we must not exaggerate, and botulism usually one realizes, "
- again, my left eyelid started to fall slightly (ptosis), which means that the toxin has spread and has an effect on my lifter eyelid ...

remains to understand why my reaction to botox eyelid, not my ocular muscles, while it's still where the injection was made! The ophthalmologist
I explained that botulinum toxin blocks the transmission at the neuromuscular junction, it is likely that the spasms and nystagmus have a myogenic origin strictly , making them insensitive to the effect of the toxin . I would not have a disruption of the order, but a pure muscle spasticity associated with something a bit "chaotic" muscles, which gives the appearance of nystagmus. Nystagmus which incidentally is not synchronous on the 2 eyes (sometimes unilaterally, sometimes on a vertical and horizontal eye on the other ...). For now, we embark on an explanation of this type. The ophthalmologist will still apply their views to the 2 strabologues CHU Nantes.

Regarding the retina : I gave him the report of the ERG increased to Nantes and leaves evoke a problem on the cone of the left eye. He said that the protocol used was insufficient to conclude, therefore he speak to the clinic Sourdille Nantes to make a complete study: ERG with dark adaptation, EPI, EOG and visual field. Then it turns out there actually reaching the retina, we could possibly make connections, which might help in the diagnosis ...

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